Article
Environmental levels of the antiviral oseltamivir induce development of resistance mutation H274Y in influenza A/H1N1 virus in mallards.
PloS one - 1 Jan 2011
Järhult Josef D, Muradrasoli Shaman, Wahlgren John, Söderström Hanna, Orozovic Goran, Gunnarsson Gunnar, Bröjer Caroline, Latorre-Margalef Neus, Fick Jerker, Grabic Roman, Lennerstrand Johan, Waldenström Jonas, Lundkvist Ake, Olsen Björn
Abstract excerpt
Oseltamivir (Tamiflu®) is the most widely used drug against influenza infections and is extensively stockpiled worldwide as part of pandemic preparedness plans. However, resistance is a growing problem and in 2008-2009, seasonal human influenza A/H1N1 virus strains in most parts of the world carried the mutation H274Y in the neuraminidase gene which causes resistance to the drug. The active metabolite of...
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