Platelets enhance tissue factor protein and metastasis initiating cell markers, and act as chemoattractants increasing the migration of ovarian cancer cells.

doi:10.1186/s12885-015-1304-z

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Article

Platelets enhance tissue factor protein and metastasis initiating cell markers, and act as chemoattractants increasing the migration of ovarian cancer cells.

BMC cancer - 15 Apr 2015

Orellana Renan, Kato Sumie, Erices Rafaela, Bravo María Loreto, Gonzalez Pamela, Oliva Bárbara, Cubillos Sofía, Valdivia Andrés, Ibañez Carolina, Brañes Jorge, Barriga María Isabel, Bravo Erasmo, Alonso Catalina, Bustamente Eva, Castellon Enrique, Hidalgo Patricia, Trigo Cesar, Panes Olga, Pereira Jaime, Mezzano Diego, Cuello Mauricio A, Owen Gareth I

Abstract excerpt

BACKGROUND: An increase in circulating platelets, or thrombocytosis, is recognized as an independent risk factor of bad prognosis and metastasis in patients with ovarian cancer; however the complex role of platelets in tumor progression has not been fully elucidated. Platelet activation has been associated with an epithelial to mesenchymal transition (EMT), while Tissue Factor (TF) protein expression by cancer...

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Identifiers

PMID: 25886038
DOI: 10.1186/s12885-015-1304-z
PMCID: PMC4410584

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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