Article
Intratumoral Delivery of IL-21 Overcomes Anti-Her2/Neu Resistance through Shifting Tumor-Associated Macrophages from M2 to M1 Phenotype.
Journal of immunology (Baltimore, Md. : 1950) - 15 May 2015
Xu Meng, Liu Mingyue, Du Xuexiang, Li Sirui, Li Hang, Li Xiaozhu, Li Ying, Wang Yang, Qin Zhihai, Fu Yang-Xin, Wang Shengdian
Abstract excerpt
Tumor resistance is a major hurdle to anti-Her2/neu Ab-based cancer therapy. Current strategies to overcome tumor resistance focus on tumor cell-intrinsic resistance. However, the extrinsic mechanisms, especially the tumor microenvironment, also play important roles in modulating the therapeutic...
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