Article
Clonal analysis of the quasispecies of antiviral-resistant HBV genomes in patients with entecavir resistance during rescue treatment and successful treatment of entecavir resistance with tenofovir.
Antiviral therapy - 1 Jan 2013
Karatayli Ersin, Idilman Ramazan, Karatayli Senem C, Cevik Emrah, Yakut Mustafa, Seven Gülseren, Kabaçam Gökhan, Bozdayi A Mithat, Yurdaydin Cihan
Abstract excerpt
BACKGROUND: Clonal analysis of quasispecies of resistant HBV genomes in patients with entecavir (ETV) resistance receiving lamivudine (3TC) plus adefovir (ADV) rescue therapy has never been performed. METHODS: A sample of 10 patients with ETV resistance who were switched to 3TC+ADV treatment were analysed for changes in viral quasispecies. Serum samples at baseline, and at months 3 and 6 of 3TC+ADV treatment...
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