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Article

Functional dissection of osteoprotegerin and its interaction with receptor activator of NF-kappaB ligand.

The Journal of biological chemistry - 16 Dec 2005

Schneeweis Lumelle A, Willard Derril, Milla Marcos E

Abstract excerpt

The receptor activator of NF-kappaB (RANK) belongs to the neuregulin/tumor necrosis factor (TNF) receptor superfamily and is activated by RANK ligand (RANK-L), a homotrimeric, TNF-like cytokine. RANK is present on the surface of osteoclast cell precursors, where its interaction with RANK-L induces their terminal differentiation into osteoclasts, thus increasing bone breakdown. The secreted, soluble receptor...

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Identifiers

PMID: 16215261
DOI: 10.1074/jbc.M506366200

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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