Article
Infrequent DNA methylation of miR-9-1 and miR-9-3 in multiple myeloma.
Journal of clinical pathology - 1 Jul 2015
Zhang Qi, Wang Lu Qian, Wong Kwan Yeung, Li Zhen Yu, Chim Chor Sang
Abstract excerpt
AIMS: The miR-9 family microRNAs (miRNAs) are tumour suppressor miRNAs implicated in carcinogenesis. We postulated that miR-9-1, miR-9-2 and miR-9-3 may be inactivated by aberrant promoter methylation in multiple myeloma (MM). METHODS: Methylation of miR-9-1, miR-9-2 and miR-9-3 was studied by methylation-specific PCR (MSP) in six normal controls, including three each of healthy peripheral blood (PB) or bone...
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