Article
Inherited variability in a master regulator polymorphism (rs4846126) associates with survival in 5-FU treated colorectal cancer patients.
Mutation research - 1 Jan 2000
Pardini Barbara, Bermejo Justo Lorenzo, Naccarati Alessio, Di Gaetano Cornelia, Rosa Fabio, Legrand Carine, Novotny Jan, Vodicka Pavel, Kumar Rajiv
Abstract excerpt
BACKGROUND: Treatment with 5-fluorouracil (5-FU) is known to improve survival in many cancers including colorectal cancer. Response to the treatment, overall survival and recurrence show inter-individual variation. METHODS: In this study we employed a strategy to search eQTL variants influencing the expression of a large number of genes. We identified four single nucleotide polymorphisms, defined as master...
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