Article
A rare truncating BRCA2 variant and genetic susceptibility to upper aerodigestive tract cancer.
Journal of the National Cancer Institute - 1 May 2015
Delahaye-Sourdeix Manon, Anantharaman Devasena, Timofeeva Maria N, Gaborieau Valérie, Chabrier Amélie, Vallée Maxime P, Lagiou Pagona, Holcátová Ivana, Richiardi Lorenzo, Kjaerheim Kristina, Agudo Antonio, Castellsagué Xavier, Macfarlane Tatiana V, Barzan Luigi, Canova Cristina, Thakker Nalin S, Conway David I, Znaor Ariana, Healy Claire M, Ahrens Wolfgang, Zaridze David, Szeszenia-Dabrowska Neonilia, Lissowska Jolanta, Fabianova Eleonora, Mates Ioan Nicolae, Bencko Vladimir, Foretova Lenka, Janout Vladimir, Curado Maria Paula, Koifman Sergio, Menezes Ana, Wünsch-Filho Victor, Eluf-Neto José, Boffetta Paolo, Fernández Garrote Leticia, Polesel Jerry, Lener Marcin, Jaworowska Ewa, Lubiński Jan, Boccia Stefania, Rajkumar Thangarajan, Samant Tanuja A, Mahimkar Manoj B, Matsuo Keitaro, Franceschi Silvia, Byrnes Graham, Brennan Paul, McKay James D
Abstract excerpt
Deleterious BRCA2 genetic variants markedly increase risk of developing breast cancer. A rare truncating BRCA2 genetic variant, rs11571833 (K3326X), has been associated with a 2.5-fold risk of lung squamous cell carcinoma but only a modest 26% increase in breast cancer risk. We analyzed the association between BRCA2 SNP rs11571833 and upper aerodigestive tract (UADT) cancer risk with multivariable unconditional...
Read the complete abstract on PubMed