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Article

The -308G/A polymorphism of the tumor necrosis factor-alpha gene is associated with the risk of upper aerodigestive tract cancer: a meta-analysis.

The Tohoku journal of experimental medicine - 1 Apr 2013

Wang Jiayi, Jin Xin, Wang Hui, Yang Jiantang, Wang Lili, Lei Lei, Li Xiaoxu, Zhou Yu, Zeng Xin, Jiang Lu, Liao Ga, Dan Hongxia, Chen Qianming

Abstract excerpt

Tumor necrosis factor-alpha (TNF-α) has been proposed to contribute to the development of upper aerodigestive tract (UADT) cancer that is characterized by poor prognosis. The G-to-A nucleotide change at -308 of the TNF-α gene (-308G/A polymorphism) can increase the expression level of TNF-α and thus may affect the genetic susceptibility of UADT cancer. The association between the -308G/A polymorphism and UADT...

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Identifiers

PMID: 23594457
DOI: 10.1620/tjem.229.245

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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