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Article

TNF-α-induced depressive-like phenotype and p38(MAPK) activation are abolished by ascorbic acid treatment.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Jun 2015

Moretti Morgana, Budni Josiane, Freitas Andiara Espíndola, Neis Vivian Binder, Ribeiro Camille Mertins, de Oliveira Balen Grasiela, Rieger Débora Kurrle, Leal Rodrigo Bainy, Rodrigues Ana Lúcia S

Abstract excerpt

We investigated the effects of ascorbic acid on depressive-like behavior induced by tumor necrosis factor (TNF-α) in mice. Additionally, we examined the effects of combined administration of ascorbic acid and antidepressants, MK-801 and 7-nitroindazole in mice exposed or not to TNF-α and the capacity of TNF-α and ascorbic acid to modulate hippocampal and cerebrocortical phosphorylation of extracellular...

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PMID: 25836357
DOI: 10.1016/j.euroneuro.2015.03.006

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TNF
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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