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Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells

23 Mar 2015

Abstract excerpt

Cancer stem cells (CSCs) with enhanced tumorigenicity and chemoresistance are believed to be responsible for treatment failure and tumor relapse in ovarian cancer patients. However, it is still unclear how CSCs survive DNA-damaging agent treatment. Here, we report an elevated expression of DNA polymerase η (Pol η) in ovarian CSCs isolated from both ovarian cancer cell lines and primary tumors, indicating that...

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PMID: 25831546
DOI: 10.1073/pnas.1421365112

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