Optimal experimental design and sample size for the statistical evaluation of data from somatic mutation and recombination tests (SMART) in Drosophila.

Abstract excerpt

In genetic toxicology it is important to know whether chemicals should be regarded as clearly hazardous or whether they can be considered sufficiently safe, which latter would be the case from the genotoxicologist's view if their genotoxic effects are nil or at least significantly below a predefined minimal effect level. A previously presented statistical decision procedure which allows one to make precisely this...

Topics

• Animals
• Chi-Square Distribution
• Drosophila melanogaster
• Eye Color
• Female
• Genetic Variation
• Male
• Maximum Allowable Concentration
• Models, Genetic
• Models, Statistical
• Mutagenicity Tests