Article
Frequency of Mycobacterium tuberculosis-specific CD8+ T-cells in the course of anti-tuberculosis treatment.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 1 Mar 2015
Axelsson-Robertson Rebecca, Rao Martin, Loxton Andre G, Walzl Gerhard, Bates Matthew, Zumla Alimuddin, Maeurer Markus
Abstract excerpt
Anti-tuberculosis drug treatment is known to affect the number, phenotype, and effector functionality of antigen-specific T-cells. In order to objectively gauge Mycobacterium tuberculosis (MTB)-specific CD8+ T-cells at the single-cell level, we developed soluble major histocompatibility complex (...
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