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Morphological and molecular characteristics of HER2 amplified urothelial bladder cancer

25 Mar 2015

Abstract excerpt

Several (pre-) clinical trials are currently investigating the benefit of HER2-targeted therapy in urothelial bladder cancer (UBC). Patients with HER2 amplified UBC could potentially profit from these therapies. However, little is known about histomorphology, HER2 protein expression patterns and occurrence of alterations in the HER2 gene in their tumors. Among 150 metastasizing primary UBC, 13 HER2 amplified...

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PMID: 25809292
DOI: 10.1007/s00428-015-1729-4

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