Article
HER2 protein overexpression and gene amplification in upper urinary tract urothelial carcinoma-an analysis of 171 patients.
International journal of clinical and experimental pathology - 1 Jan 2014
Sasaki Yuka, Sasaki Takeshi, Kawai Taketo, Morikawa Teppei, Matsusaka Keisuke, Kunita Akiko, Kume Haruki, Aoki Ichiro, Homma Yukio, Fukayama Masashi
Abstract excerpt
Upper urinary tract urothelial carcinomas (UUTUC) are infrequent and show an occurrence of about 5-10% of all urothelial carcinomas. In this study, we investigated the HER2 status of 171 UUTUC patients with nephroureterectomy. The number of patients is the largest of any HER2 study. All 171 cases were analyzed for both HER2 overexpression using immunohistochemistry and HER2 gene amplification using dual-color in...
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