Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MYC amplification in multiple marker chromosomes and EZH2 microdeletion in a man with acute myeloid leukemia.

Cancer genetics - 1 Mar 2015

Xiang Zhifu, Abdallah Al-Ola, Govindarajan Rangaswamy, Mehta Paulette, Emanuel Peter D, Papenhausen Peter, Schichman Steven A

Abstract excerpt

The role of MYC and EZH2 in acute myeloid leukemia (AML) pathogenesis is poorly understood. Herein we present a case of AML with MYC amplification in marker chromosomes and a microdeletion of chromosome 7 below cytogenetic resolution. The karyotype of the patient's bone marrow aspirate showed three to five marker chromosomes in all dividing cells without other structural or numerical chromosomal abnormalities....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Enhancer of Zeste Homolog 2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Gene Deletion

Share to Genes, myc

Share to In Situ Hybridization, Fluorescence

Share to Leukemia, Myeloid, Acute

Share to Polycomb Repressive Complex 2

Source

Identifiers

PMID: 25800664
DOI: 10.1016/j.cancergen.2015.01.010

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

MYC amplification in multiple marker chromosomes and EZH2 microdeletion in a man with acute myeloid leukemia.PMID 25800664Read ↗

Disclosure of Candidate Genes in Acute Myeloid Leukemia With Complex Karyotypes Using Microarray-Based Molecular CharacterizationSemantic proximity Read ↗

Integrative study of EZH2 mutational status, copy number, protein expression and H3K27 trimethylation in AML/MDS patients.Semantic proximity Read ↗

Loss of heterozygosity in 7q myeloid disorders: clinical associations and genomic pathogenesis.Semantic proximity Read ↗

DNA profiling by arrayCGH in acute myeloid leukemia and myelodysplastic syndromes.Semantic proximity Read ↗

Chromosome 7q31.1 deletion in myeloid neoplasms.Semantic proximity Read ↗

Identification of a commonly amplified 4.3 Mb region with overexpression of C8FW, but not MYC in MYC-containing double minutes in myeloid malignanciesSemantic proximity Read ↗

Spectral karyotyping in patients with acute myeloid leukemia and a complex karyotype shows hidden aberrations, including recurrent overrepresentation of 21q, 11q, and 22qSemantic proximity Read ↗

Single nucleotide polymorphism genomic arrays analysis of t(8;21) acute myeloid leukemia cells.Semantic proximity Read ↗

Molecular Cytogenetic Delineation of Deletions and Translocations Involving Chromosome Band 7q22 in Myeloid LeukemiasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.