Article
Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.
The Journal of clinical investigation - 1 Apr 2015
Knowles Joshua W, Xie Weijia, Zhang Zhongyang, Chennamsetty Indumathi, Chennemsetty Indumathi, Assimes Themistocles L, Paananen Jussi, Hansson Ola, Pankow James, Goodarzi Mark O, Carcamo-Orive Ivan, Morris Andrew P, Chen Yii-Der I, Mäkinen Ville-Petteri, Ganna Andrea, Mahajan Anubha, Guo Xiuqing, Abbasi Fahim, Greenawalt Danielle M, Lum Pek, Molony Cliona, Lind Lars, Lindgren Cecilia, Raffel Leslie J, Tsao Philip S, Schadt Eric E, Rotter Jerome I, Sinaiko Alan, Reaven Gerald, Yang Xia, Hsiung Chao A, Groop Leif, Cordell Heather J, Laakso Markku, Hao Ke, Ingelsson Erik, Frayling Timothy M, Weedon Michael N, Walker Mark, Quertermous Thomas
Abstract excerpt
Decreased insulin sensitivity, also referred to as insulin resistance (IR), is a fundamental abnormality in patients with type 2 diabetes and a risk factor for cardiovascular disease. While IR predisposition is heritable, the genetic basis remains largely unknown. The GENEticS of Insulin Sensitiv...
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