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Article

Polymorphisms of IKBKE gene are associated with major depressive disorder and panic disorder.

Brain and behavior - 1 Apr 2015

Traks Tanel, Koido Kati, Balõtšev Roman, Eller Triin, Kõks Sulev, Maron Eduard, Tõru Innar, Shlik Jakov, Vasar Eero, Vasar Veiko

Abstract excerpt

BACKGROUND: The immune system has been increasingly implicated in the development of mood and anxiety disorders. Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase epsilon (IKBKE) gene encodes IKKε protein that is involved in innate immunity, predominantly antiviral response generation. It also bears pro-inflammatory properties that could affect psychiatric outcomes. In order to investigate the...

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Identifiers

PMID: 25798331
DOI: 10.1002/brb3.314
PMCID: PMC4356867

Genes

IKBKE

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