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Article

Factor-induced Reprogramming and Zinc Finger Nuclease-aided Gene Targeting Cause Different Genome Instability in β-Thalassemia Induced Pluripotent Stem Cells (iPSCs).

The Journal of biological chemistry - 8 May 2015

Ma Ning, Shan Yongli, Liao Baojian, Kong Guanyi, Wang Cheng, Huang Ke, Zhang Hui, Cai Xiujuan, Chen Shubin, Pei Duanqing, Chen Nansheng, Pan Guangjin

Abstract excerpt

The generation of personalized induced pluripotent stem cells (iPSCs) followed by targeted genome editing provides an opportunity for developing customized effective cellular therapies for genetic disorders. However, it is critical to ascertain whether edited iPSCs harbor unfavorable genomic vari...

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Identifiers

PMID: 25795783
DOI: 10.1074/jbc.M114.624999
PMCID: PMC4424344

Genes

HBB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25795783-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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