Article
Production of phenocopies by Krüppel antisense RNA injection into Drosophila embryos.
Nature - 1 Jan 2000
Rosenberg U B, Preiss A, Seifert E, Jäckle H, Knipple D C
Abstract excerpt
The demonstration that a specific messenger RNA can be functionally inactivated in vivo by hybridization to complementary polynucleotide sequences suggests a direct approach to the study of gene function in cells of higher organisms. The experiments described here were designed to inhibit, by com...
Topics
- Animals
- Drosophila melanogaster
- Gene Expression Regulation
- Microinjections
- Mutation
- Phenotype
- RNA
- RNA, Messenger