Article
N-acetylglucosamine modification in the lumen of the endoplasmic reticulum.
Biochimica et biophysica acta - 1 Jun 2015
Ogawa Mitsutaka, Sawaguchi Shogo, Furukawa Koichi, Okajima Tetsuya
Abstract excerpt
BACKGROUND: O-linked β-N-acetylglucosamine (O-GlcNAc) modification of epidermal growth factor (EGF) domains catalyzed by EGF domain O-GlcNAc transferase (EOGT) is the first example of GlcNAc modification in the lumen of the endoplasmic reticulum (ER). SCOPE OF REVIEW: This review summarizes current knowledge on the EOGT-catalyzed O-GlcNAc modification of EGF domains obtained through biochemical characterization,...
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