Article
GTDC2 modifies O-mannosylated α-dystroglycan in the endoplasmic reticulum to generate N-acetyl glucosamine epitopes reactive with CTD110.6 antibody.
Biochemical and biophysical research communications - 11 Oct 2013
Ogawa Mitsutaka, Nakamura Naosuke, Nakayama Yoshiaki, Kurosaka Akira, Manya Hiroshi, Kanagawa Motoi, Endo Tamao, Furukawa Koichi, Okajima Tetsuya
Abstract excerpt
Hypoglycosylation is a common characteristic of dystroglycanopathy, which is a group of congenital muscular dystrophies. More than ten genes have been implicated in α-dystroglycanopathies that are associated with the defect in the O-mannosylation pathway. One such gene is GTDC2, which was recently reported to encode O-mannose β-1,4-N-acetylglucosaminyltransferase. Here we show that GTDC2 generates CTD110.6...
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