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Aranciamycins I and J, Antimycobacterial Anthracyclines from an Australian Marine-Derived <i>Streptomyces</i> sp.

19 Mar 2015

Abstract excerpt

Chemical analysis of an Australian marine-derived Streptomyces sp. (CMB-M0150) yielded two new anthracycline antibiotics, aranciamycins I (1) and J (2), as well as the previously reported aranciamycin A (3) and aranciamycin (4). The aranciamycins 1-4, identified by detailed spectroscopic analysis, were noncytotoxic when tested against selected Gram-negative bacteria and fungi (IC50 >30 μM) and exhibited moderate...

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PMID: 25789410
DOI: 10.1021/acs.jnatprod.5b00095

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