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Cytotoxic Angucycline Class Glycosides from the Deep Sea Actinomycete <i>Streptomyces lusitanus</i> SCSIO LR32

3 Feb 2012

Abstract excerpt

Five new C-glycoside angucyclines, named grincamycins B-F (1-5), and a known angucycline antibiotic, grincamycin (6), were isolated from Streptomyces lusitanus SCSIO LR32, an actinomycete of deep sea origin. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses, including MS and 1D and 2D NMR experiments. All compounds except grincamycin F (5) exhibited in vitro...

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PMID: 22304344
DOI: 10.1021/np2008335

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