Article
Tracking the in vivo evolution of multidrug resistance in Staphylococcus aureus by whole-genome sequencing.
Proceedings of the National Academy of Sciences of the United States of America - 29 May 2007
Mwangi Michael M, Wu Shang Wei, Zhou Yanjiao, Sieradzki Krzysztof, de Lencastre Herminia, Richardson Paul, Bruce David, Rubin Edward, Myers Eugene, Siggia Eric D, Tomasz Alexander
Abstract excerpt
The spread of multidrug-resistant Staphylococcus aureus (MRSA) strains in the clinical environment has begun to pose serious limits to treatment options. Yet virtually nothing is known about how resistance traits are acquired in vivo. Here, we apply the power of whole-genome sequencing to identif...
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