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Article

RyR2 Common Gene Variant G1886S and the Risk of Ventricular Arrhythmias in ICD Patients with Heart Failure.

Journal of cardiovascular electrophysiology - 1 Jun 2015

Francia Pietro, Adduci Carmen, Semprini Lorenzo, Stanzione Rosita, Serdoz Andrea, Caprinozzi Massimo, Santini Daria, Cotugno Maria, Palano Francesca, Musumeci Maria Beatrice, Rubattu Speranza, Volpe Massimo

Abstract excerpt

BACKGROUND: Cardiac ryanodine receptor 2 (RyR2) is critical to the electrical homeostasis of cardiomyocytes. Its gene variant rs3766871 entails channel destabilization and enhanced intracellular Ca(2+) oscillation, thus promoting cardiac arrhythmias. We investigated whether the RyR2 rs3766871 var...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cross-Sectional Studies
Share to Death, Sudden, Cardiac
Share to Defibrillators, Implantable
Share to Genotyping Techniques
Share to Heart Failure
Share to Ryanodine Receptor Calcium Release Channel
Share to Tachycardia, Ventricular
Share to Ventricular Fibrillation

Source

Identifiers

PMID: 25773045
DOI: 10.1111/jce.12658

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-25773045-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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