Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons.

Neuroscience - 21 May 2015

Li R, Xu D-E, Ma T

Abstract excerpt

Statins are a class of cholesterol-lowering drugs and have been suggested therapeutic use for neurodegenerative diseases including Alzheimer's disease (AD). Our recent studies revealed a neuronal protective effect of lovastatin (LOV) from N-methyl-d-aspartic acid (NMDA) excitotoxicity. The neurop...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Frontotemporal Dementia
Share to Lovastatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neurons

Share to Okadaic Acid

Share to Phosphorylation

Share to Rats, Sprague-Dawley

Share to tau Proteins

Source

Identifiers

PMID: 25770969
DOI: 10.1016/j.neuroscience.2015.03.005

Genes

CDK2
CDK5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25770969-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Lovastatin suppresses the aberrant tau phosphorylation from FTDP-17 mutation and okadaic acid-induction in rat primary neurons.PMID 25770969Read ↗

Riluzole: a therapeutic strategy in Alzheimer’s disease by targeting the WNT/β-catenin pathwaySemantic proximity Read ↗

Exploring the molecular mechanisms underlying neuroprotective effect of ellagic acid in okadaic acid-induced Alzheimer's phenotype.Semantic proximity Read ↗

Physiological and Pathological Roles of Cdk5: Potential Directions for Therapeutic Targeting in Neurodegenerative DiseaseSemantic proximity Read ↗

Verapamil Inhibits Ser202/Thr205 Phosphorylation of Tau by Blocking TXNIP/ROS/p38 MAPK Pathway.Semantic proximity Read ↗

Amyloid-ß promotes neurotoxicity by Cdk5-induced p53 stabilizationSemantic proximity Read ↗

Cdk5 is involved in NFT-like tauopathy induced by transient cerebral ischemia in female ratsSemantic proximity Read ↗

The complex p25/Cdk5 kinase in neurofibrillary degeneration and neuronal death: The missing link to cell cycleSemantic proximity Read ↗

Pro-apoptotic effects of tau mutations in chromosome 17 frontotemporal dementia and parkinsonism.Semantic proximity Read ↗

CYP46A1 protects against NMDA-mediated excitotoxicity in Huntington's disease: Analysis of lipid raft content.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.