Article
RNAseq expression patterns of canine invasive urothelial carcinoma reveal two distinct tumor clusters and shared regions of dysregulation with human bladder tumors.
BMC cancer - 24 Mar 2020
Parker Heidi G, Dhawan Deepika, Harris Alex C, Ramos-Vara Jose A, Davis Brian W, Knapp Deborah W, Ostrander Elaine A
Abstract excerpt
BACKGROUND: Invasive urothelial carcinoma (iUC) is highly similar between dogs and humans in terms of pathologic presentation, molecular subtypes, response to treatment and age at onset. Thus, the dog is an established and relevant model for testing and development of targeted drugs benefiting both canine and human patients. We sought to identify gene expression patterns associated with two primary types of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.