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Article

From solution to gas phase: the implications of intramolecular interactions on the evaporative dynamics of substance P during electrospray ionization.

The journal of physical chemistry. B - 2 Apr 2015

Servage Kelly A, Silveira Joshua A, Fort Kyle L, Russell David H

Abstract excerpt

Substance P (RPKPQQFFGLM-NH2) [M + 3H](3+) ions have been shown to occupy two distinct conformer states, a compact population of conformers that is formed by evaporation of hydrated ions, and an elongated population of conformers that is formed by collisional heating of the compact conformer. Molecular dynamics (MD) simulations and amino acid mutations revealed that the compact conformer is stabilized by...

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PMID: 25760225
DOI: 10.1021/jp512708u

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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