Article
Energetics of the interaction between water and the helical peptide group and its role in determining helix propensities.
Proceedings of the National Academy of Sciences of the United States of America - 26 Sept 2000
Avbelj F, Luo P, Baldwin R L
Abstract excerpt
The alanine helix provides a model system for studying the energetics of interaction between water and the helical peptide group, a possible major factor in the energetics of protein folding. Helix formation is enthalpy-driven (-1.0 kcal/mol per residue). Experimental transfer data (vapor phase to aqueous) for amides give the enthalpy of interaction with water of the amide group as approximately -11.5 kcal/mol....
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