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From mTOR to cognition: molecular and cellular mechanisms of cognitive impairments in tuberous sclerosis

20 Aug 2009

Abstract excerpt

BACKGROUND: Tuberous sclerosis (TSC) is a multi-system disorder caused by heterozygous mutations in the TSC1 or TSC2 gene and is often associated with neuropsychiatric symptoms, including intellectual disability, specific neuropsychological deficits, autism, other behavioural disorders and epilepsy. METHOD: Here, we review evidence from animal models of TSC for the role of specific molecular and cellular...

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PMID: 19694899
DOI: 10.1111/j.1365-2788.2009.01208.x

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