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Article

PI3K/AKT/mTOR pathway is activated after imatinib secondary resistance in gastrointestinal stromal tumors (GISTs).

Medical oncology (Northwood, London, England) - 1 Apr 2015

Li Jian, Dang Yunzhi, Gao Jing, Li Yanyan, Zou Jianling, Shen Lin

Abstract excerpt

Phosphatidylinositol-3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) pathway activation may be related to imatinib resistance; however, no study has focused on whether signal conduction of this pathway will change after imatinib resistance. A total of 111 GIST samples from 91 patients were used in this study, including 20 pairs of samples before and after imatinib treatment. Immunohistochemistry was...

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Share to Gastrointestinal Stromal Tumors
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Immunoenzyme Techniques

Share to Lymphatic Metastasis

Share to Proto-Oncogene Proteins c-akt

Share to Proto-Oncogene Proteins c-kit

Share to PTEN Phosphohydrolase

Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 25757539
DOI: 10.1007/s12032-015-0554-6

Genes

KIT
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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