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Article

PIK3CA/PTEN mutations and Akt activation as markers of sensitivity to allosteric mTOR inhibitors.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Mar 2012

Meric-Bernstam Funda, Akcakanat Argun, Chen Huiqin, Do Kim-Anh, Sangai Takafumi, Adkins Farrell, Gonzalez-Angulo Ana Maria, Rashid Asif, Crosby Katherine, Dong Mei, Phan Alexandria T, Wolff Robert A, Gupta Sanjay, Mills Gordon B, Yao James

Abstract excerpt

PURPOSE: We sought to determine whether phosphoinositide 3-kinase (PI3K) pathway mutation or activation state and rapamycin-induced feedback loop activation of Akt is associated with rapamycin sensitivity or resistance. EXPERIMENTAL DESIGN: Cancer cell lines were tested for rapamycin sensitivity, Akt phosphorylation, and mTOR target inhibition. Mice injected with breast or neuroendocrine cancer cells and patients...

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Share to Antibiotics, Antineoplastic
Share to Carcinoma, Neuroendocrine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Everolimus

Share to PTEN Phosphohydrolase

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Source

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Identifiers

PMID: 22422409
DOI: 10.1158/1078-0432.CCR-11-2123
PMCID: PMC3307149

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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