Article

SGPL1 Deficiency Get Involved in Imatinib Resistance via PI 3 K-Akt signaling pathway in gastrointestinal stromal tumor

2025-05-28

Abstract excerpt

<title>Abstract</title> <p> Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the gastrointestinal tract. In recent years, secondary resistance to the first-line drug imatinib has become its bottleneck of targeted therapy due to the unclear mechanism. It has important clinical significance for breaking through the bottleneck by screening and identifying the critical gene of imatinib r...

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Literature Corpus work: ab1eb5e1-50e0-51c2-8990-9cb034ddb9ff
DOI: 10.21203/rs.3.rs-6647302/v1

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