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Article

Association of symptoms and severity of rift valley fever with genetic polymorphisms in human innate immune pathways.

PLoS neglected tropical diseases - 1 Mar 2015

Hise Amy G, Traylor Zachary, Hall Noémi B, Sutherland Laura J, Dahir Saidi, Ermler Megan E, Muiruri Samuel, Muchiri Eric M, Kazura James W, LaBeaud A Desirée, King Charles H, Stein Catherine M

Abstract excerpt

BACKGROUND: Multiple recent outbreaks of Rift Valley Fever (RVF) in Africa, Madagascar, and the Arabian Peninsula have resulted in significant morbidity, mortality, and financial loss due to related livestock epizootics. Presentation of human RVF varies from mild febrile illness to meningoencephalitis, hemorrhagic diathesis, and/or ophthalmitis with residual retinal scarring, but the determinants for severe...

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Identifiers

PMID: 25756647
DOI: 10.1371/journal.pntd.0003584
PMCID: PMC4355584

Genes

TLR8
MAVS
TLR3
TLR7
IFNAR1
TICAM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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