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Article

Long-term follow-up of STAT5B deficiency in three argentinian patients: clinical and immunological features.

Journal of clinical immunology - 1 Apr 2015

Bezrodnik Liliana, Di Giovanni Daniela, Caldirola María Soledad, Azcoiti María Esnaola, Torgerson Troy, Gaillard María Isabel

Abstract excerpt

UNLABELLED: The signal transducer and activator of transcription (STAT) family of proteins regulate gene transcription in response to a variety of cytokines. STAT5B, in particular, plays an important role in T cells, where it is a key mediator of interleukin-2 (IL-2) induced responses. STAT5B deficiency causes a rare autosomal recessive disorder reported in only a handful of individuals. There are currently ten...

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Identifiers

PMID: 25753012
DOI: 10.1007/s10875-015-0145-5

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