Article
Using Amplicon Deep Sequencing to Detect Genetic Signatures of Plasmodium vivax Relapse.
The Journal of infectious diseases - 15 Sept 2015
Lin Jessica T, Hathaway Nicholas J, Saunders David L, Lon Chanthap, Balasubramanian Sujata, Kharabora Oksana, Gosi Panita, Sriwichai Sabaithip, Kartchner Laurel, Chuor Char Meng, Satharath Prom, Lanteri Charlotte, Bailey Jeffrey A, Juliano Jonathan J
Abstract excerpt
Plasmodium vivax infections often recur due to relapse of hypnozoites from the liver. In malaria-endemic areas, tools to distinguish relapse from reinfection are needed. We applied amplicon deep sequencing to P. vivax isolates from 78 Cambodian volunteers, nearly one-third of whom suffered recurrence at a median of 68 days. Deep sequencing at a highly variable region of the P. vivax merozoite surface protein 1...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.