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Article

Hypnozoite depletion in successive Plasmodium vivax relapses

22 Jul 2022

Abstract excerpt

Genotyping Plasmodium vivax relapses can provide insights into hypnozoite biology. We performed targeted amplicon sequencing of 127 relapses occurring in Indonesian soldiers returning to malaria-free Java after yearlong deployment in malarious Eastern Indonesia. Hepatic carriage of multiple hypnozoite clones was evident in three-quarters of soldiers with two successive relapses, yet the majority of relapse...

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PMID: 35867730
DOI: 10.1371/journal.pntd.0010648

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