Article
Individual Plasmodium vivax msp1 variants within polyclonal P. vivax infections display different propensities for relapse.
Journal of clinical microbiology - 1 Apr 2012
Lin Jessica T, Juliano Jonathan J, Kharabora Oksana, Sem Rithy, Lin Feng-Chang, Muth Sinuon, Ménard Didier, Wongsrichanalai Chansuda, Rogers William O, Meshnick Steven R
Abstract excerpt
Using a newly developed Plasmodium vivax merozoite surface protein 1 gene (Pvmsp1) heteroduplex tracking assay, we genotyped 107 P. vivax infections in individuals from Cambodia, 45 of whom developed recurrent parasitemia within 42 days. The majority of isolates were polyclonal, but recurrent parasitemias displayed fewer variants compared to initial parasitemias. Two Pvmsp1 gene variants occurred more frequently...
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