Article
Multiple-clone activation of hypnozoites is the leading cause of relapse in Plasmodium vivax infection.
PloS one - 1 Jan 2012
de Araujo Flávia Carolina F, de Rezende Antônio Mauro, Fontes Cor Jesus F, Carvalho Luzia Helena, Alves de Brito Cristiana F
Abstract excerpt
BACKGROUND: Plasmodium vivax infection is characterized by a dormant hepatic stage, the hypnozoite that is activated at varying periods of time after clearance of the primary acute blood-stage, resulting in relapse. Differentiation between treatment failure and new infections requires characterization of initial infections, relapses, and clone multiplicity in vivax malaria infections. METHODOLOGY/PRINCIPAL...
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