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Article

Amplification refractory mutation system for prenatal diagnosis and carrier assessment in cystic fibrosis.

Lancet (London, England) - 1 Jan 2000

Newton C R, Heptinstall L E, Summers C, Super M, Schwarz M, Anwar R, Graham A, Smith J C, Markham A F

Abstract excerpt

The amplification refractory mutation system (ARMS) has been applied to prenatal diagnosis and carrier detection of cystic fibrosis. The nucleotide sequence of both alleles of the PstI restriction fragment length polymorphism at the KM19 locus, which displays linkage disequilibrium with cystic fibrosis, has been determined. ARMS enables direct analysis of alleles of this polymorphism in DNA isolated from...

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PMID: 2574768
DOI: 10.1016/s0140-6736(89)92931-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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