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Article

βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes.

Scientific reports - 4 Mar 2015

Valapala Mallika, Edwards Malia, Hose Stacey, Hu Jianfei, Wawrousek Eric, Lutty Gerard A, Zigler J Samuel, Qian Jiang, Sinha Debasish

Abstract excerpt

We have previously reported that in the Nuc1 rat, which has a spontaneous mutation in Cryba1 (the gene encoding βA3/A1-crystallin), astrocytes exhibit decreased Notch signaling, leading to reduced promoter activity for glial fibrillary acidic protein (GFAP). Interestingly, in both Nuc1 astrocytes and in wild type astrocytes following knockdown of Cryba1, vascular endothelial growth factor (VEGF) secretion is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Microscopy, Confocal

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Share to Receptors, Notch

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Source

Open in PubMed Open full text

Identifiers

PMID: 25736717
DOI: 10.1038/srep08755
PMCID: PMC4348628

Genes

STAT3
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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