Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes.

Scientific reports - 4 Mar 2015

Valapala Mallika, Edwards Malia, Hose Stacey, Hu Jianfei, Wawrousek Eric, Lutty Gerard A, Zigler J Samuel, Qian Jiang, Sinha Debasish

Abstract excerpt

We have previously reported that in the Nuc1 rat, which has a spontaneous mutation in Cryba1 (the gene encoding βA3/A1-crystallin), astrocytes exhibit decreased Notch signaling, leading to reduced promoter activity for glial fibrillary acidic protein (GFAP). Interestingly, in both Nuc1 astrocytes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Crystallins
Share to Immunoblotting

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Confocal

Share to Optic Nerve

Share to Phosphorylation

Share to Receptors, Notch

Share to STAT3 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 25736717
DOI: 10.1038/srep08755
PMCID: PMC4348628

Genes

STAT3
GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25736717-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

βA3/A1-crystallin is a critical mediator of STAT3 signaling in optic nerve astrocytes.PMID 25736717Read ↗

betaA3/A1-crystallin in astroglial cells regulates retinal vascular remodeling during development.Semantic proximity Read ↗

An astrocyte BMAL1-BAG3 axis protects against alpha-synuclein and tau pathologySemantic proximity Read ↗

STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease.Semantic proximity Read ↗

CRYβA3/A1-Crystallin Knockout Develops Nuclear Cataract and Causes Impaired Lysosomal Cargo Clearance and Calpain Activation.Semantic proximity Read ↗

Upregulated SEMA3C in astrocytes contributes to Rett Syndrome phenotypesSemantic proximity Read ↗

Signaling molecules regulating phenotypic conversions of astrocytes and glial scar formation in damaged nerve tissues.Semantic proximity Read ↗

DYRK1A overexpression enhances STAT activity and astrogliogenesis in a Down syndrome mouse modelSemantic proximity Read ↗

Juxtacrine DLL4-NOTCH1 signaling between astrocytes drives neuroinflammation via the IL-6-STAT3 axisSemantic proximity Read ↗

STAT3 but Not STAT1 Is Required for Astrocyte DifferentiationSemantic proximity Read ↗

Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease.Semantic proximity Read ↗

Analysis of mouse lens morphological and proteomic abnormalities following depletion of βB3-crystallinSemantic proximity Read ↗

Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.