The β2‐Glycoprotein I/HLA–DR Complex As a Major Autoantibody Target in Obstetric Antiphospholipid Syndrome

Abstract excerpt

Objective The clinical manifestations of antiphospholipid syndrome (APS) include vascular thrombosis and pregnancy morbidity as well as recurrent pregnancy loss (RPL). However, in more than half of patients with RPL, the cause is never determined. Recently, β2‐glycoprotein I (β2GPI) complexed with HLA class II molecules (β2GPI/HLA‐DR) was found to be a major autoantibody target in APS. The present study was...

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