A Coding Variant of ANO10, Affecting Volume Regulation of Macrophages, Is Associated with Borrelia Seropositivity.

doi:10.2119/molmed.2014.00219

Article

A Coding Variant of ANO10, Affecting Volume Regulation of Macrophages, Is Associated with Borrelia Seropositivity.

Molecular medicine (Cambridge, Mass.) - 23 Feb 2015

Hammer Christian, Wanitchakool Podchanart, Sirianant Lalida, Papiol Sergi, Monnheimer Mathieu, Faria Diana, Ousingsawat Jiraporn, Schramek Natalie, Schmitt Corinna, Margos Gabriele, Michel Angelika, Kraiczy Peter, Pawlita Michael, Schreiber Rainer, Schulz Thomas F, Fingerle Volker, Tumani Hayrettin, Ehrenreich Hannelore, Kunzelmann Karl

Abstract excerpt

In a first genome-wide association study (GWAS) approach to anti-Borrelia seropositivity, we identified two significant single nucleotide polymorphisms (SNPs) (rs17850869, P = 4.17E-09; rs41289586, P = 7.18E-08). Both markers, located on chromosomes 16 and 3, respectively, are within or close to genes previously connected to spinocerebellar ataxia. The risk SNP rs41289586 represents a missense variant (R263H) of...

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