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Article

PSCA rs2294008 polymorphism contributes to the decreased risk for cervical cancer in a Chinese population.

Scientific reports - 22 Mar 2016

Wang Shizhi, Wu Shenshen, Zhu Haixia, Ding Bo, Cai Yunlang, Ni Jing, Wu Qiang, Meng Qingtao, Zhang Xin, Zhang Chengcheng, Li Xiaobo, Wang Meilin, Chen Rui, Jin Hua, Zhang Zhengdong

Abstract excerpt

Recently, three genome-wide association studies have identified the PSCA (prostate stem cell antigen) rs2294008 polymorphism (C > T) associated with susceptibility to gastric cancer, bladder cancer, and duodenal ulcers, highlighting its critical role in disease pathogenesis. Given PSCA is reported to be overexpressed in cervical cancer and the rs2294008 can influence PSCA transcription, we aimed to determine the...

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Open in PubMed Open full text

Identifiers

PMID: 27001215
DOI: 10.1038/srep23465
PMCID: PMC4802316

Genes

PSCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PSCA rs2294008 polymorphism contributes to the decreased risk for cervical cancer in a Chinese population.PMID 27001215Read ↗

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PSCA polymorphisms and gastric cancer susceptibility in an eastern Chinese population.Semantic proximity Read ↗

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Variants in thePSCAgene associated with risk of cancer and nonneoplastic diseases: systematic research synopsis, meta-analysis and epidemiological evidenceSemantic proximity Read ↗

The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis.Semantic proximity Read ↗

Polymorphisms in prostate stem cell antigen gene rs2294008 increase gastric cancer risk in Chinese.Semantic proximity Read ↗

rs2294008T, a risk allele for gastric and gallbladder cancers, suppresses the PSCA promoter by recruiting the transcription factor YY1.Semantic proximity Read ↗

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