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Article

Social responsiveness, an autism endophenotype: genomewide significant linkage to two regions on chromosome 8.

The American journal of psychiatry - 1 Mar 2015

Lowe Jennifer K, Werling Donna M, Constantino John N, Cantor Rita M, Geschwind Daniel H

Abstract excerpt

OBJECTIVE: Autism spectrum disorder is characterized by deficits in social function and the presence of repetitive and restrictive behaviors. Following a previous test of principle, the authors adopted a quantitative approach to discovering genes contributing to the broader autism phenotype by using social responsiveness as an endophenotype for autism spectrum disorder. METHOD: Linkage analyses using scores from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25727539
DOI: 10.1176/appi.ajp.2014.14050576
PMCID: PMC4523091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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