A Replicative Plasmid Vector Allows Efficient Complementation of Pathogenic Leptospira Strains

Abstract excerpt

Leptospirosis, an emerging zoonotic disease, remains poorly understood because of a lack of genetic manipulation tools available for pathogenic leptospires. Current genetic manipulation techniques include insertion of DNA by random transposon mutagenesis and homologous recombination via suicide vectors. This study describes the construction of a shuttle vector, pMaORI, that replicates within saprophytic,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Leptospirosis research and findings
• Share to Veterinary medicine and infectious diseases
• Share to Viral gastroenteritis research and epidemiology