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Article

Combined effect of CYP2B6 and NAT2 genotype on plasma efavirenz exposure during rifampin-based antituberculosis therapy in the STRIDE study.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Jun 2015

Luetkemeyer Anne F, Rosenkranz Susan L, Lu Darlene, Grinsztejn Beatriz, Sanchez Jorge, Ssemmanda Michael, Sanne Ian, McIlleron Helen, Havlir Diane V, Haas David W

Abstract excerpt

In STRIDE, slow metabolizer CYP2B6 and NAT2 genotypes were each associated with increased plasma efavirenz concentrations during antituberculosis therapy. Concentrations were greater on therapy than off therapy in 58% with CYP2B6 and 93% with NAT2 slow metabolizer genotypes. Individuals with slow metabolizer genotypes in both genes had markedly elevated concentrations.

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Identifiers

PMID: 25722197
DOI: 10.1093/cid/civ155
PMCID: PMC4542662

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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