Article
Effects of rifampin-based antituberculosis therapy on plasma efavirenz concentrations in children vary by CYP2B6 genotype.
AIDS (London, England) - 31 Jul 2013
McIlleron Helen M, Schomaker Michael, Ren Yuan, Sinxadi Phumla, Nuttall James J C, Gous Hermien, Moultrie Harry, Eley Brian, Merry Concepta, Smith Peter, Haas David W, Maartens Gary
Abstract excerpt
OBJECTIVES: An efavirenz-based antiretroviral therapy (ART) regimen is preferred for children more than 3 years of age with tuberculosis. However, rifampin, a key component of antituberculosis therapy, induces CYP2B6. An increased dose of efavirenz is recommended in adults weighing more than 50 kg who require rifampin, but there is scant information in children being treated for tuberculosis. DESIGN: Plasma...
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