Article
HER2 as a target in invasive urothelial carcinoma.
Cancer medicine - 1 Jun 2015
Bellmunt Joaquim, Werner Lillian, Bamias Aristotle, Fay André P, Park Rachel S, Riester Markus, Selvarajah Shamini, Barletta Justine A, Berman David M, de Muga Silvia, Salido Marta, Gallardo Enrique, Rojo Federico, Guancial Elizabeth A, Bambury Richard, Mullane Stephanie A, Choueiri Toni K, Loda Massimo, Stack Edward, Rosenberg Jonathan
Abstract excerpt
We evaluated primary tumors from two cohorts, Spain (N = 111) and Greece (N = 102), for patients who were treated with platinum-based chemotherapy. Patients were tested for HER2 status (IHC score of 3+ or FISH ratio of ≥ 2.2) by immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), DNA copy number, mRNA expression, and mutation status in patients with metastatic urothelial carcinoma (UC), and its...
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